Chemotherapy drugs are used in different stages of tumor cell proliferation to kill tumor cells and inhibit tumor cell proliferation or induce differentiation. According to different mechanisms of action, chemotherapy drugs commonly used in clinic can be classified into 6 classes: (1) platinum-based drugs: cisplatin, carboplatin, oxaliplatin, etc.; (2) antimetabolites: 5-fluorouracil, gemcitabine, etc.; (3) alkylating agents: cyclophosphamide, etc.; (4) DNA intercalators: anthracycline antibiotics, bleomycin, actinomycin D, etc.; (5) DNA topoisomerase I/II inhibitors: irinotecan, etoposide; (6) antimicrotubular drugs: taxol, docetaxel, vinblastine, vincristine, vinorelbine, etc.
Clinical tests prove that the interaction with chemotherapy drugs or gene mutation or expression level involved in metabolism have enormous effects on the chemotherapy efficacy. Testing of relevant gene expression level provides necessary basis for the selection of chemotherapy drugs and ensures desired effects of individualized chemotherapy.
Product list
Item | Drug | Type | Method |
TP53 gene mutation | Platinum-based drugs | Tumor | ARMS |
UGT1A1 gene polymorphism | Irinotecan | Colorectal cancer lung cancer cervical cancer | Sequencing |
CYP2D6 gene polymorphism | Tamoxifen | Breast cancer | Sequencing |
ERCC1 gene expression level | Platinum-based drugs | Tumor | △△Ct |
BRCA1 gene expression level | Platinum-based drugs | Tumor | △△Ct |
TOP2A gene expression level | Etoposide | Breast cancer | △△Ct |
STMN1 gene expression level | Vinorelbine or taxol | Tumor | △△Ct |
TUBB3 gene expression level | Taxol, vinblastine | Tumor | △△Ct |
TYMS gene expression level | Fluorouracil | Colorectal cancer lung cancer breast cancer SCCHN | △△Ct |
TYMP gene expression level | Fluorouracil | NSCLC Gastric cancer breast cancer Head cancer | △△Ct |
DPYD gene expression level | Fluorouracil | Colorectal cancer lung cancer breast cancer SCCHN | △△Ct |
RRM1 gene expression level | Gemcitabine | NSCLC Pancreatic Cancer | △△Ct |